bms 3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4600	BMS-3		LIM Kinase
	BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.		LIM Kinase
T4598	BMS-5	BMS5,LIMKi 3	LIM Kinase
	BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.		LIM Kinase
T8730	BMS986260		TGF-beta/Smad
	BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).		TGF-beta/Smad
T6418	BMS-378806	BMS378806,BMS-806	gp120/CD4 , HIV Protease
	BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.		gp120/CD4 , HIV Protease
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T7787	BMS817378		c-Met/HGFR
	BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).		c-Met/HGFR
T8326	BMS-2		VEGFR , FLT , c-Met/HGFR
	BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.		VEGFR , FLT , c-Met/HGFR
T7309	TAS-103 dihydrochloride	TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.		Topoisomerase
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
T29140	VU0652925	VU 0652925,BMS-3,VU-0652925,BMS3,BMS 3
	VU0652925 is a PAR4 antagonist. VU0652925 has a P-sel IC50 of 39.2 pM (-pIC50±SEM: 10.41±0.04) and a PAC1 IC50 of 43.0 pM (-pIC50±SEM: 10.4±0.04).
T10349	Apixaban 13C,d3	Apixaban 13CD3,BMS-562247-01 13CD3	Others
	Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium-labeled Apixaban. Apixaban is a reversible inhibitor of Factor Xa (Ki: 0.08 nM and 0.17 nM in human and rabbit).		Others
T14681	BMS-935177		BTK
	BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.		BTK
T14680	BMS-906024	Osugacestat,AL-101,BM-0018	Gamma-secretase
	BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-...		Gamma-secretase
T4532	Linrodostat	BMS-986205	IDO , Indoleamine 2,3-Dioxygenase (IDO)
	Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.		IDO , Indoleamine 2,3-Dioxygenase (IDO)
T26869	BMS-986122	BMS 986122	Opioid Receptor
	BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...		Opioid Receptor
T6036	Brivanib	BMS-540215	EGFR , VEGFR , FGFR , Autophagy
	Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.		EGFR , VEGFR , FGFR , Autophagy
T9901A-001	Relatlimab	BMS-986016	Others
	Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, bloc...		Others
T6229	Daclatasvir	Daklinza,EBP 883,BMS-790052	HCV Protease
	Daclatasvir (EBP 883) (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.		HCV Protease
T30502	BMS-194449	93ZDV2P17I,UNII-93ZDV2P17I,CHEMBL320915,BMS194449
	BMS-194449 is a full beta 3 agonist.